Biohacking human abilities and the future of CRISPR

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We are comfortable altering our bodies to maintain our abilities: laser eye surgery, hip replacements, hearing implants… What about genetically enhancing our abilities? Is this different?

Imagine three men, all of them 82 years old and generally healthy. But they are all quite different.

The first man is mostly bald with gray hair over his ears, hunched over, walks with a cane, wears thick glasses, has hearing aids, has bent fingers from arthritis, and his hands shake slightly… and although he has a couple stints in his veins, he has no life-threatening ailments. Unless he meets an unexpected or untimely death, he will likely see his 85th birthday.

The second man has had his genetic makeup altered by CRISPR, taking advantage of human genes being altered to reduce the effects of aging. He looks 55-60 years old, with a full head of hair, greying near his ears, an upright posture, 20-20 vision, good hearing, and steady hands, unaffected by arthritis… his cardiovascular health is like that of someone fit and in their 50’s. He has no life-threatening ailments. Unless he meets an unexpected or untimely death, he will likely see his 100th birthday.

The third man has had his genetic makeup altered by CRISPR, taking advantage of animal and plant genes being altered to enhance his life. His hair is naturally jet black, and has an attractive but unnaturally beautiful shimmer. His eyesight is as good as a hawk’s, 20/2 vision, meaning he can see something 20 feet away as if it is just 2 feet away. His hearing range is more like a dogs than a human… His muscles are huge and he has the physical and cardiovascular health of a man in his late 30’s. He has no life-threatening ailments. Unless he meets an unexpected or untimely death, he will likely see his 125th birthday, and he will still have the mental acuity of a man 1/3 his age.

My hunch is that you are not bothered at all by the health improvements of the second man, but the idea of the third man is a bit disturbing. We are ok with the idea of reducing the effects of aging… skin creams, laser eye surgery, cochlear hearing implants, plastic surgery, knee and hip replacements. All these things to help us hold on to our youth, and if we can do these things genetically, that’s great.

But the third man seems unnatural in a way that is scary. He seems more than human. He seems to be an enhanced species. And here is the truly scary thing… he is inevitable. We now live in a world where people consider themselves biohackers… self-taught amateurs who are DIY (Do-It-Yourself) biologists. And the technology is becoming easy enough for a person in their basement to alter the genes of a human being.

Stop and really think about that for a moment. An amateur biologist can alter the genes of a dog, and there is nothing to stop him from attempting to do the same to himself. This isn’t science fiction anymore. And if a DIY, basement biologist alters their own genetic makeup, then decides to have children, those genetic alterations will become part of the human genome. We are going to see altered and enhanced human abilities added to the genetic makeup of our future generations… with no oversight!

The question isn’t if this will happen, it’s how soon, by whom, and with what unforeseen consequences? Will biohackers be designing super humans? Will being an unaltered human 75 years from now be disadvantageous? Will these disadvantages be enough to be considered a sub-class of a super being… An upgraded human that is smarter, stronger, healthier, and lives longer, with more vitality in their later years, which will make a regular human being seem weak, and perhaps stupid too.

This is the stuff that science fiction is made of, and it’s happening right now. It’s happening in biomedical labs bound by ethics boards; And it’s happening unsupervised in the basements and garages of biohackers with both good and nefarious intentions. That’s both a very real and very scary concern to think about.

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